Most common tablet defects at compression stage of manufacturing
Tablet defects occur because of various reasons, which can be easily prevented from occurrence. To eliminate the possibility of defects in the tablets, the process of tablet manufacturing should be fully understood by the manufacturer.
Adequate scientific and academic knowledge along with hands-on training for tablet manufacturing, setting of the machine, and continuous monitoring plays a vital role in manufacturing high-quality tablets.
The technician should have adequate knowledge about the setting of the machine, trouble shooting, and the skill to operate the machine to manufacture high-quality products.
What are the common tablet defects at compression stage?
There are four commonly used methods for testing powder flow:
(01) Weight variation
(02) High friability
(03) High or low hardness (resistance to crushing)
(04) Sticking
(05) Picking
(06) Capping
(07) Laminating
(08) Chipping
(09) Mottling
(10) Double press or impression
(11) Cracking
(12) Binding
(13) Edging or Flashing of tablet
(14) Disintegration time abnormality
(15) Black Spot/ particles/ fiber
(16) Improper embossing or debossing
(17) Layer separation
(18) Improper Layers
To read more on each one Click Here
